个人概况

姓名：徐宇嘉

性别：女

民族：汉族

技术职称：教授

导师类型：硕导（学术型）

最后学历：研究生

最后学位：博士

工作单位：成人卡通 。

邮箱：[email protected]

个人简介

从事肿瘤基础研究，累计发表SCI论文20篇。主要从肿瘤临床分子标志事件出发，结合分子生物学和生物信息学技术探索肿瘤发生、耐药及转移的驱动因素，开发新型抗肿瘤靶点及个体化药物，为肿瘤的临床治疗提供理论基础。

学习和科研经历

2022/10至今：成人卡通 ，成人卡通 ，教授

2020/09-2022/06：成人卡通 ，博后

2014/09-2020/06：苏州大学，博士

2010/09-2014/06：湖北中医药大学，药学，学士

研究方向

1.探索肿瘤代谢异常调控机制

2.开发设计靶向肿瘤代谢异常的药物及治疗策略

主持科研项目

1.国家自然科学基金（青年项目），82100214，RNF6自身泛素化的调控机制及其在多发性骨髓瘤中的作用研究，2022/01-2024/12，30万，结题，主持。

2.国家自然科学基金（面上项目），82370211，转录因子MafB通过蛋白酶体通路降解的分子调控机制及其在多发性骨髓瘤治疗中的意义研究，2024-01 至2027-12，48万元，在研，主持

3.2022年成人卡通 高水平大学建设项目，200万

部分代表性第一和通讯作者论文

1.Yujia Xu; Min Xu; Jiefei Tong; Xiaowen Tang; Jinhao Chen; Xuehan Chen; Zubin Zhang; Biyin Cao; A.Keith Stewart; Michael F. Moran; Depei Wu; Xinliang Mao ; Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma, Blood, 2021, 137(11): 1478-1490  

2.Yujia Xu; Zubin Zhang; Jie Li; Jiefei Tong; Biyin Cao; Paul Taylor; Xiaowen Tang; Depei Wu; Michael F. Moran; Yuanying Zeng; Xinliang Mao; The ubiquitin-conjugating enzyme UBE2O modulates c-Maf stability and induces myeloma cell apoptosis, Journal of Hematology Oncology, 2017, 10(3)  

3.Haixia Zhuang; Ying Ren; Chenyu Mao; Yueya Zhong; Zubin Zhang; Biyin Cao; Yuming Zhang; Jinqi Huang; Guoqiang Xu; Zhenqian Huang; Yujia Xu; Xinliang Mao ; Induction of zinc finger protein RNF6 auto-ubiquitination for the treatment of myeloma and chronic myeloid leukemia, Journal of Biological Chemistry, 2022, 298(9): 102314-102314  

4.Yujia Xu; Tong Sun; Kun Zeng; Min Xu; Jinhao Chen; Xiaofeng Xu; Zubin Zhang; Biyin Cao; Xiaowen Tang; Depei Wu; Yan Kong; Yuanying Zeng; Xinliang Mao; Anti-bacterial and anti-viral nanchangmycin displays anti-myeloma activity by targeting Otub1 and c-Maf, Cell Death &Disease, 2020, 11(9)  

5.Tong Sun; Yujia Xu; Zhuan Xu; Biyin Cao; Zubin Zhang; Qi Wang; Yan Kong; Xinliang Mao; Inhibition of the Otub1/c-Maf axis by the herbal acevaltrate induces myeloma cell apoptosis, Cell Communication and Signaling, 2021, 19(1)  

6.Xue-han Chen; Yu-jia Xu; Xiao-ge Wang; Peng Lin; Bi-yin Cao; Yuan-ying Zeng; Qi Wang; Zu-bin Zhang; Xin-liang Mao and Tie Zhang. Mebendazole elicits potent antimyeloma activity by inhibiting the USP5/c-Maf axis, Acta Pharmacologica Sinica (2019) 40:1568–1577  

7.Tong Sun; Yu-jia Xu; Shuo-yi Jiang; Zhuan Xu; Bi-yin Cao; Gautam Sethi; Yuan-ying Zeng; Yan Kong and Xin-liang Mao; Suppression of the USP10/CCND1 axis induces glioblastoma cell apoptosis, Acta Pharmacologica Sinica (2021) 42:1338–1346

8.Yu-jia Xu; Kun Zeng; Ying Ren; Chen-yu Mao; Ying-hui Ye; Xiao-ting Zhu; Zi-ying Sun; Bi-yin Cao; Zu-bin Zhang; Guo-qiang Xu; Zhen-qian Huang and Xin-liang Mao, Inhibition of USP10 induces myeloma cell apoptosis by promoting cyclin D3 degradation, Acta Pharmacologica Sinica (2023) 0:1–12